人への初回投与試験でコロナ・ウィルスのワクチンから安全で速い防御免疫応答が得られることが判明: Lancet に論文が発表される






Zhu FC, Li YH, Guan XH, et al. Safety, tolerability, and immunogenicity of a recombinant adenovirus type-5 vectored COVID-19 vaccine: a dose-escalation, open-label, non-randomised, first-in-human trial. [published online ahead of print May 22, 2020]. Lancet. doi:


科学者たちが研究室でコロナウィルスを撃退する抗体を製造することに成功 Nature Communicationsに論文が発表される

ブルームバーグのネット版に2020年5月5日に科学者たちが研究室でコロナウィルスを撃退する抗体を作り出すことに成功した記事が掲載されました。この研究の詳細は5月4日にNature Communicationsに出版された以下の文献を基に作成されています。

Nature Communicationsに出版されたこの英語論文へのリンク

以下はその記事(Loh, 2020)を和訳し一部解説を加えたものです。

Scientists Create Antibody That Defeats Coronavirus in Lab


Scientists created a monoclonal antibody that can defeat the new coronavirus in the lab, an early but promising step in efforts to find treatments and curb the pandemic’s spread.


The experimental antibody has neutralized the virus in cell cultures.


While that’s early in the drug development process — before animal research and human trials — the antibody may help prevent or treat Covid-19 and related diseases in the future, either alone or in a drug combination, according to a study published Monday in the journal Nature Communications.

2020年5月4日(月)にNature Communicationsに出版されたこの研究によるとこの抗体はCovid-19やそれに関連したウィルスを単独であるいは他の薬との組み合わせにより防いだり治療したりすることに役立つかもしれないことが示唆された。もちろんこの研究は新薬開発の初期段階の過程のひとつで実際にこの抗体が臨床に活用されるまでには動物実験を経て人間での治験が必要になる。

More research is needed to see whether the findings are confirmed in a clinical setting and how precisely the antibody defeats the virus, Berend-Jan Bosch of Utrecht University in the Netherlands and colleagues wrote in the paper.

この研究の著者であるユトレヒト大学の ベーレント・ジャン・ボッシュ氏らはまだこの抗体が実際どのようにコロナウィルスを撃退するのかについてのより多くの知見が必要であり、実際にこの抗体が臨床の現場でコロナウィルスが撃退できるかについて確認されなければならないことを述べている。

The antibody known as 47D11 targets the spike protein that gives the new coronavirus a crown-like shape and lets it enter human cells.


In the Utrecht experiments, it didn’t just defeat the virus responsible for Covid-19 but also a cousin equipped with similar spike proteins, which causes Severe Acute Respiratory Syndrome, or SARS.


Monoclonal antibodies are lab-created proteins that resemble naturally occurring versions the body raises to fight off bacteria and viruses.


Highly potent, they target exactly one site on a virus.


In this case, the scientists used genetically modified mice to produce different antibodies to the spike proteins of coronaviruses.


After a subsequent screening process, 47D11 emerged as showing neutralizing activity.


Researchers then reformatted that antibody to create a fully human version, according to the paper.


“Monoclonal antibodies targeting vulnerable sites on viral surface proteins are increasingly recognized as a promising class of drugs against infectious diseases and have shown therapeutic efficacy for a number of viruses,” Bosch and colleagues wrote.


Monoclonal antibodies already sparked a treatment revolution in cancer, with medicines such as Merck & Co.’s Keytruda and Roche Holding AG’s Herceptin becoming some of the world’s bestsellers.


AbbVie Inc.’s blockbuster inflammation treatment Humira is also part of the monoclonal antibody family.


Two such antibody therapies show promise against Ebola.


Companies such as Regeneron Pharmaceuticals Inc. are also working on possible antibody treatments for the coronavirus.



Loh T. (2020, May 5). Scientists create antibody that defeats coronavirus in lab [ News article] . Retrieved from

Wang, C., Li, W., Drabek, D. et al. A human monoclonal antibody blocking SARS-CoV-2 infection. Nat Commun 11, 2251 (2020).

FireShot Capture 228 - Coronavirus COVID-19 (2019-nCoV) -










このマップに載っている死亡者数、感染者数などのデータは世界保健機構(WHO)米国疾病管理予防センター(CDC)欧州疾病予防管理センター(ECDC )また、中国の疾病管理予防センター(CCDC)などから集計されたデータを活用しています。

また、このデータはマップ下部のDownloadable database: GitHub: Here.と書いたところをクリックするとGitHubで統計データがダウンロードできるようになっています。



Bloomberg. (2020, February 6). Johns Hopkins Nuzzo says current approach to coronavirus isn’t working [Video file]. Retrieved from

Gardner L. (2020, January 23). Mapping 2019-nCoV [Blog post]. Retrieved from

John Hopkins CSSE (2020, February 7). Coronavirus 2019-nCoV global cases [Webpage]. Retrieved from



世界で蔓延している致命的な動物ウィルスは中国の秘密生物兵器プログラムと関連した武漢の研究所から発生した可能性があることをイスラエルの生物兵器の専門家が指摘している記事が1982年創刊のアメリカの保守系日刊紙であるワシントン・タイムズのネット版に2020年1月24日に掲載され世界中で物議をかもしています。以下はその記事(情報源参照: Gertz, 2020)を和訳し一部解説を加えたものです。

Virology institute there has China’s only secure lab for studying deadly viruses


Radio Free Asia this week rebroadcast a local Wuhan television report from 2015 showing China’s most advanced virus research laboratory known the Wuhan Institute of Virology, Radio Free Asia reported. The laboratory is the only declared site in China capable of working with deadly viruses.


Dany Shoham, a former Israeli military intelligence officer who has studied Chinese bio warfare, said the institute is linked to Beijin’s covert biological weapons program.


“Certain laboratories in the institute have probably been engaged, in terms of research and development, in Chinese biological weapons at least collaterally, yet not as a principal facility of the Chinese Biological Weapon alignment,” Mr.Shoham told The Washington Times.


Work on biological weapons is conducted as a part of a dual civilian-military research and is “definitely covert,” he said in an e-mail.


Mr.Shoham holds a doctorate in medical microbiology. From 1970 to 1991 he was a senior analyst with Israeli military intelligence for biological and chemical warfare in the Middle East and worldwide, holding the rank of lieutenant colonel.


China in the past has denied having any offensive biological weapons. The State Department, in a report last year, said it suspects China has engaged in covert biological warfare work.


A Chinese Embassy spokesman did not return an e-mail seeking comment.


Chinese authorities so far have said the origin of the coronavirus that has killed scores and infected hundreds in in central Hubei Province is not known.


Gao Fu, director of the Chinese Center for Disease Control and Prevention, told state-controlled media initial signs as of Thursday indicated the virus originated from wild animals sold at a seafood market in Wuhan.


One ominous sign, said a U.S. official, is that false rumors since the outbreak began several weeks ago have begun circulating on the Chinese Internet claiming the virus is part of a U.S. conspiracy to spread germ weapons.


That could indicate China is preparing propaganda outlets to counter future charges the new virus escaped from one of Wuhan’s civilian or defense research laboratories.


The World Health Organization is calling the microbe novel coronavirus 2019-nCoV. At a meeting in Geneva Thursday, the organization stopped short of declaring a Public Health Emergency of International Concern.


The virus outbreak causes pneumonia-like symptoms and prompted China to deploy military forces to Wuhan this week in a bid to halt the spread. All travel out of the city of 11 million people was halted.


The Wuhan institute has studied coronaviruses in the past, including the strain that causes Severe Acute Respiratory Syndrome, or SARS, H5N1 influenza virus, Japanese encephalitis, and dengue. Researchers at the institute also studied the germ that causes anthrax—a biological agent once developed in Russia.


“Coronaviruses (particularly SARS) have been studied in the institute and are probably held therein,” he said. “SARS is included within the Chinese BW program, at large, and is dealt with in several pertinent facilities.”


It is not known if the institute’s array of coronaviruses are specifically included in biological weapons program but it is possible, he said.


Asked if the new coronavirus may have leaked, Mr.Shoham said: “In principle, outward virus infiltration might take place either as leakage or as an indoor unnoticed infection of a person that normally went out of the concerned facility. This could have been the case with the Wuhan Institute of Virology, but so far there isn’t evidence or indication of such incident.


After researchers sequence the genome of the new coronavirus it might be possible to determine or suggest its origin or source.


Mr.Shoham, now with the Begin-Sadat Center for Strategic Studies at Bar llan University in Israel, said the virology institute is the only declared site in China known as P4 for Pathogen Level 4, a status indicating it uses the strictest safety standards to prevent the spread of the most dangerous and exotic microbes being studies.


The former Israeli military intelligence doctor also said suspicions were raised about the Wuhan Institute of Virology when a group of Chinese virologists working in Canada improperly sent samples to China of what he said were some of the deadliest viruses on earth, including the Ebola virus.


In a July article in the Journal of the Institute for Defense Studies and Analyses, Mr.Shoham said the Wuhan institute was one of four Chinese laboratories engaged in some aspects of the biological weapons development.

国防分析研究所が発行するジャーナル(the Journal of the Institute for Defense Studies and Analyses)に7月に出版された文献でショーハム氏は武漢ウィルス研究所は何らかの生物兵器開発に携わっている中国の4つの施設の内のひとつであると述べている。

He identified the secure Wuhan National Biosafety Laboratory at the institute as engaged in research on the Ebola, Nipah, and Crimean-Congo hemorrhagic fever viruses.


The Wuhan virology institute is under the Chinese Academy of Sciences. But certain laboratories within it “have linkage with the PLA or BW-related elements within the Chinese defense establishment,” he said.


In 1993, China declared a second facility, the Wuhan Institute of Biological Products, as one of eight biological warfare research facilities covered by the Biological Weapons Convention (BWC) which China joined in 1985.


The Wuhan Institute of Biological Products is a civilian facility but is linked to the Chinese defense establishment, and has been regarded to be involved in the Chinese BW program, Mr.Shoham said.


China’s vaccine against SARS is probably produced there.


“This means the SARS virus is held and propagated there, but it is not a new coronavirus, unless the wild type has been modified, which is not known and cannot be speculated at the moment,” he said.


The annual State Department report on arms treaty compliance stated last year that China engaged in activities that could support biological warfare.


“Information indicates that the People’s Republic of China engaged during the reporting period in biological threat,” the report added.


The biosafety lab is located about 20 miles from the Hunan Seafood Market that reports from China say may have been origin point of the virus.


Rutgers University microbiologist Dr.Richard Ebright told Lonodn’s Daily Mail that “at this point there’s no reason to harbor suspicions” the lab may be linked to the virus outbreak.




Gertz, B. (2020, January 24). Virus-hit Wuhan has two laboratories linked to Chinese bio-warfare program The Washington Times. Retrieved January 24, 2020 from